Saturday, September 7, 2019

Breakthrough therapy designation to capmatinib- Lung Cancer


The FDA granted breakthrough therapy designation to capmatinib for first-line treatment of metastatic MET exon 14 skipping-mutated non-small cell lung cancer.
MET mutations — identified in approximately 4% of patients with NSCLC — are associated with poor prognosis. The mutations, typically seen among older patients, can limit treatment options.
No targeted therapies are approved to treat MET exon 14 skipping-mutated NSCLC, an aggressive subtype of the disease.
Prior studies have shown capmatinib (INC280, Novartis) — an investigational, oral MET inhibitor — to be highly selective and potent in this setting, according to a Novartis-issued press release. The FDA previously granted breakthrough therapy designation to the agent for treatment of patients with this type of NSCLC who received prior platinum-based chemotherapy.
“We look forward to working with the FDA and global health authorities to bring capmatinib to patients who currently have no available targeted therapy options,” John Tsai, MD, head of global drug development and chief medical officer of Novartis, said in the release.

Tuesday, August 27, 2019

Recent Trends in Oncology


Study shows that de-intensified chemoradiotherapy regimen shows favorable clinical outcomes among for HPV-associated oropharyngeal squamous cell carcinoma. Learn more about oncology at: http://bit.ly/2Yxiv66



Thursday, August 22, 2019

Wednesday, August 21, 2019

Recent Trends in Oncology


Research reveals that combo of palbociclib & cetuximab shows antitumor activity for platinum or cetuximab resistant HPV unrelated head and neck squamous cell carcinoma. Explore more about cancer at: http://bit.ly/2K4sRl4



Recent Trends in Oncology


Study shows that breast cancer screening at a younger age prevent more than half of all breast cancer-related deaths among childhood cancer survivors treated with chest radiation. Learn more about oncology at: http://bit.ly/2Yxiv66